ABSTRACT
Introduction: In today’s world, infertility is one of themajor emerging health issues which effects about 8-9% ofreproductive age group. Infertility due to certain male factorsand complete tubal obstruction may require interventionalprocedure. Increased risk of adverse perinatal outcomes areassociated with ART. Study objctive was to asses perinataloutcome in pregnant women conceived with inventionaltechniques.Material and Methods: A Retrospective study was done attertiary care hospital from January 2018 to June 2018. anddata was collected. The maternal and fetal condition werenoted as per records.Results: Women > 40 years of age had 11.53% of intrauterinedeath, 65.38% requires NICU admission, 11.53% requiresventilator support and 7.69% had neonatal death.Study alsorevealed foetal complications like intra uterine death (pvalue=0.0004), fetal anomalies, IUGR (P value=0.0003)which were atleast four times more in ART group than inspontaneous conception.Study also revealed that out of 167new born in ART group,there were 28.74% having verylow birth weight,19.76% were having low birth weight and51.50% had adequate weight, i.e around half of them werehaving weight less than 2 kgs as compared to spontaneouspregnancy group were only 5.71% i.e 6 babies were born lessthan 2 kg weight(P value < .0001 highly significant).Conclusion: Maternal age was significantly associatedwith perinatal and obstetrical complications. To improvematernal and perinatal outcomes, pre-existing diseases likehypertension, anaemia, diabetes mellitus and hypothyroidismshould be treated before conception. Overall aim should beto minimize iatrogenic preterm birth for minor ailments,close supervision of such women can add few more weeks topregnancy thus improving neonatal outcome.
ABSTRACT
Background: Guillain barre syndrome (GBS) is an immune mediated polyneuropathy characterized by progressive weakness and variety of symptoms including muscle paralysis, autonomic dysfunction and respiratory involvement that affect one or two persons in 100,000 population. Although immunotherapies including therapeutic plasma exchange (TPE), immunoglobulins (IVIg) and corticosteroids are the available beneficial modes of treatment, the residual symptoms are disabling and long lasting and require long term rehabilitation. Observational studies and RCT on multi-disciplinary care has proven exercises to be an answer to residual long lasting disability. Supervised individually designed exercise prescription after physiotherapy assessment may play a major role in minimizing disability.Methods: The present study is an open-level, parallel, superiority randomized control trial with blinding of outcome assessors to evaluate the results of the individually designed exercise programme over home based exercise programme. 74 adult referred GBS patients will be recruited and randomize in two groups either to receive 12 weeks individually designed exercise programme or home based exercise programme. The primary outcome shall be assessed as functional independence in activities of daily living and secondary outcomes shall be evaluated in terms of muscle strength, fatigue, pain, and quality of life at baseline, six months and twelve months duration.Conclusions: This is the first randomized control trial to compare the effect of supervised individually designed exercise over home based exercise programme on pwGBS.Trial registration: Currently the trial is ethically approved, prospectively registered CTRI/2016/08/007150 and in the process of recruiting its first subjects.